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To evaluate whether one could achieve the therapeutic potential of CD40L blockade while removing the TE risk hypothesized to be due to platelet activation, this paper describes the generation and testing of an anti-CD40L antibody fragment lacking a functional Fc region.
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We further investigated the interaction between magnesium and calcium levels on aggressive or high-grade prostate cancer risk, hypothesizing that inadequate serum magnesium levels reflected by a high serum ratio of calcium to magnesium will be associated with more aggressive prostate cancer.
ORs per "high-risk" (hypothesized poor detoxification) allele (PON1 108T, FMO1 9536A, and BCHE539T) were greater among children whose homes had been treated during childhood than among children whose homes never had been treated.
The risk is hypothesized, not proved; it was suggested in a single Vioxx study and not in studies of Celebrex.
Because moderate alcohol intake appears to reduce cardiovascular disease risk, we hypothesized that moderate alcohol intake is associated with better pulmonary function.
From our study alone, it is not clear whether social status among coyotes has a true effect on the pathogen-exposure risk as hypothesized for other social-mammal systems [45], [46].
This ostensible decreased risk is hypothesized to result from exposure to endotoxins contained in cotton dust.
The causal pathway through which exercise influences breast cancer risk is hypothesized to be predominantly hormone mediated, i.e. metabolic and sex hormones [ 3].
and IGF-1 [ 34] levels have been linked to increased risk for breast cancer and/or recurrence, our findings suggest that CYP1A2 function is associated with increased rather than decreased breast cancer risk as hypothesized.
This increased tumor risk is hypothesized to account for, in part, the significantly higher ability to form pluripotent embryonal carcimona (EC) cell lines and ESC lines in this mouse strain (Brook and Gardner, 1997).
We explored whether the association between HIV infection and hip, vertebral, and upper arm fractures in men could be explained by traditional fragility fracture risk factors, hypothesizing that these risk factors would explain much of the association between HIV infection and fragility fractures.
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