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Patients with psoriasis on biologic therapies and a history of viral hepatitis carry a risk for reactivation.
American Thoracic Society guidelines recommend a 9-month course of therapy with isoniazid for treatment of persons with latent tuberculosis infection who are at high risk for reactivation of disease.
It is reasonable to assume that a significant proportion of critically ill patients are at risk for reactivation of these herpes viruses.
The risk for reactivation of latent TBC or developing new disease during ABC treatment has not been evaluated.
Unfortunately, the patients receiving this therapy are at higher risk for bacterial or fungal infections, and at risk for reactivation of latent viral infections and latent tuberculosis.
Patients with solid tumours and haematological malignancies have—to different degrees an increased risk for reactivation or primary acquisition of viral infections.
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Increasing age and immune suppression are well-recognised risk factors for reactivation of varicella zoster virus [19], which causes herpes zoster.
A high prevalence of reactivation of hepatitis B has been documented among immunosuppressed individuals in the inactive phase of chronic hepatitis B; However, the proportion of and the risk factors for reactivation are largely unknown among non-immunosuppressed persons.
However, our data suggest that renal failure requiring renal replacement therapy is as potent a risk factor for reactivation of TB as any (including HIV infection) previously described.
HIV+ patients with OBI may be at risk for HBV reactivation, and often receive dual active anti-HBV/HIV therapy, such as lamivudine (LMV).
In contrast, few studies investigated CMV reactivation and end-organ disease in patients undergoing Autologous Peripheral Blood Stem Cell Transplant (ASCT) since they are considered at low risk for both reactivation and disease.
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