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The risk explained by the interactions is assessed concurrently and further elaborate searches may be guided by the results of such analyses.
The proportion of variation in BE risk explained by common variants has been estimated to be 35%.
The harmful effect of anemia is greater than the increased risk explained by the need for transfusion [ 20].
The overall model performance can be measured using R, which characterizes the degree of variation in risk explained by the model.
Taking these new loci into account, the proportion of familial risk explained by common genetic loci is now estimated at 28% for breast cancer [ 8], 4% for ovarian cancer [ 28] and 30% for prostate cancer [ 9].
An increased risk of cardiovascular disease is well established in inflammatory rheumatic diseases such as systemic lupus erythematosus and rheumatoid arthritis [ 3], over and above the risk explained by conventional cardiovascular risk factors.
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This example illustrates the large difference in familial risks explained by markers and causative variants.
These differing patterns of breast cancer risk are not easily explained by known risk factor distributions [ 7].
% excess risk explained is calculated by [(OR base – OR adj) /(OR base – 1)]*100.
Girls had a 1.74-time higher SA risk than boys, and 45% of the risk was explained by socioeconomic, school, and mental difficulties and violence.
Much of the increase in diabetes risk was explained by adjustment for these and other strong risk factors for diabetes, as has been reported in prior studies (6, 7, 16).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com