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Therefore, the TEFs do not reflect the relative potency comparison across the PCDD/F AhR ligands in humans, the range of variability and uncertainty in overall relative potency of a congener or the critical risk end point of cancer.
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To do so, an ecosystem integrity risk assessment matrix was constructed with 42 risk end points.
We added cardiovascular risk end points (lipids and glucose) to support the primary outcome.
Therefore, the primary risk model end point was grade ≥2 HFSR as defined by the NCIC CTC over the first 8 weeks of therapy.
To visualize the number of patients at risk in relation to the risk for end points, the distribution of the CER as a histogram along with the curve showing HRs over the range of CERs is shown in Fig. 1.
In the U.K. Prospective Diabetes Study, each 1% reduction in A1C was associated with a 37% decrease in relative risk for microvascular complications and a 21% decrease in relative risk of any end point or death related to diabetes (2).
We found no interaction between xanthelasmata and arcus corneae on risk of any end point.
Risk of any end point (complication or death) became significantly higher at A1C ≥8.0%.
The sibutramine group had a 9.7% increased risk for primary end point plus revascularization procedures relative to the placebo group (P = 0.051).
13 Thirdly, we needed to make assumptions that compliance with scheduled clinic visits was independent of the risk of the end point to justify our statistical approach.
The pros and cons of composite end points in prognostic research are discussed, and an adaptation method, designed to accurately adjust absolute risks for a composite end point to risks for the individual component outcomes, is presented.
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