There was evidence of a cumulative risk effect, suggesting that exposure to higher numbers of risk factors, regardless of their exact nature, resulted in increased behaviour difficulties.
Sophisticated molecular testing indicates that the common epilepsies are very polygenic without evidence of any single gene having even a mild-to-modest risk effect.
The pedigree disequilibrium test (PDT) and the genotype-PDT were used to test the risk effect of APOE.
Aggregate effects of all risk loci on AAO were examined in a burden analysis using genotype scores weighted by risk effect sizes.
Likewise, synthetic pyrethroids recorded a combined health risk effect of 2.57 × 10−3, suggesting that people who patronize vegetables may not experience adverse health impacts in their lifetime.
For the majority of IBS patients, the genetic background will be constituted by a large set of common genetic variants, each contributing a small risk effect.
The most common haplotype GCA (in order of Asp 312 Asn, Asp 711 Asp and Lys 751 Gln) also exhibited significant risk effect on NSCLC survival (log-rank P = 0.001).
To the best of our knowledge, the high copy number of ABCF1 had the strongest risk effect on the pathogenesis of gout in males (OR 5.70, P = 0.002) than any other genetic factors that had previously been reported.
Our results revealed both a maternal protective effect and a fetal risk effect.
In this scenario, each mutation might have a different degree of risk effect.
However, the risk effect acts as a bias of the random drift which is the mechanism of extinction in otherwise equivalent organisms.
