Sentence examples for risk breed from inspiring English sources

These findings were supported by the high and low risk breed groups and suggested an association of ESR1 alleles with increased risk of CMTs.

Multiple testing correction using 10,000 permutations for the ESS dataset and 10 permutations for the high and low risk breed dataset was also performed.

A large number of SNPs, among them several SNPs in ESR1, showed significantly different allele frequencies between the high and low risk breed groups (best P Bonf  = 8.8E-32, best P BPerm  = 0.076).

Considering each individual breed as the study unit rather than the individual dog, we performed pairwise correlation analysis for the high and low risk breed dataset using JMP 8 (SAS Institute Inc., North Carolina, USA).

However, there were considerable inter-breed variations in SNP allele frequencies for the high and low risk dataset also within the high and low risk breed groups (Table  6).

Firstly, every single tooth in every dog was analysed around the whole of the gingival margin; secondly the breed studied (miniature schnauzer) is known to be a high risk breed for periodontitis (internal data – unpublished) and thirdly the very earliest stages of periodontitis were measured.

Another challenge is the documentation of high and low risk breeds.

In the second dataset, 237 dogs of high risk breeds, 191 dogs of low risk breeds and 43 SNPs passed quality control and were included in the study of allele frequencies (Table  1).

Single SNP and haplotype analysis were performed separately for the two different study datasets; the ESS cases were compared to the controls, and the high risk breeds from the Canine Biobank were all compared to the low risk breeds.

Assumed low risk breeds included in the study were the Beagle, Bernese Mountain Dog, Collie and Shetland Sheepdog [ 3- 8].

Moreover, the dogs from the high and low risk breeds in our study are randomly selected without knowledge about the CMT phenotype.