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The median and 95th percentile risk values of toilet-flushing using treated stormwater are below U.S. EPA annual risk benchmark of ≤ 10− 4 pppy, whereas the disease burdens of both toilet-flushing and showering are within the WHO recommended disease burdens of ≤ 10− 6 DALYs pppy.
Average formaldehyde levels in this study correspond to concentrations above the EPA 1 in 10 lifetime cancer risk benchmark [ 53].
Recent analyses suggest that 49% of New York City residents live in census tracts exceeding the 1 in 10,000 HAP-attributable cancer risk benchmark compared to 4.8% of the population nationwide, with the majority of the risk attributed to benzene and formaldehyde exposures [ 10, 11].
Age, body mass index, use of nonsteroidal anti-inflammatory drugs, and blood lead levels were used as covariates for estimated GFR. BMDs/BMDLs corresponding to an additional risk (benchmark response) of 5 or 10% were calculated (the background risk at zero exposure was set to 5%).
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Institutional money managers are more prone to short-term portfolio shifts, because they are usually judged on a quarterly basis and adjust their allocations to conform with risk benchmarks.
These results confirm the safety of stormwater application in toilet flushing, but call for further research to fill the data gaps in risk modeling as well as risk benchmarks.
Short exposure duration and less-protective cancer risk benchmarks.
City-wide average temporally adjusted springtime measurements of benzene correspond to concentrations between EPA's 1 in 10 and 10 lifetime cancer risk benchmarks [ 52].
In the 2008 above-reported study from China by Sun et al. [ 94], these risk benchmarks were surpassed at SF levels measured in the third quartiles among both male and female populations.
The questionable assumptions include six main issues: a) high consumer body weight, b) low estimates of seafood consumption, c) failure to include a cancer risk assessment for naphthalene, d) failure to adjust for early-life susceptibility to PAHs, e) short exposure duration, and f ) high cancer risk benchmarks.
Given that the U.S. EPA determined that those estimates were protective of health within an 870-fold margin of error (U.S. EPA 2006), our results do not suggest unacceptable risk using the risk benchmarks employed in that assessment, which are based on thresholds of cholinesterase inhibition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com