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This would allow healthcare teams to risk adapting their psychological screening and support processes.
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Here, we investigate the effect of HPV-status, smoking habit and treatment design on overall survival (OS) and progression free survival (PFS) of 126 patients with tonsillar SCC (TSCC) who underwent CO2-laser-surgery and risk adapted adjuvant treatment.
We predict that when applied to large cohorts of patients enrolled in clinical trials, this integrated epigenomics approach will provide more accurate disease classification and more powerful prognostic information, which could be then used to design improved risk adapted and targeted therapy clinical trials.
We retrospectively evaluated the effectiveness and safety of this risk adapted postnatal transmission prophylaxis regimen.
However, no stratification of these patients into risk adapted therapy groups has been established.
Individual risk adapted follow-up examinations in future guidelines designed for optimal disease management are proposed [ 39, 40].
Therefore, risk adapted therapy approaches have been developed including allogenic stem cell transplantation as well as targeted therapies.
More recently, risk adapted strategies for use of plerixafor have substantially reduced the failure rate in these patients.
In the era of risk adapted therapy approaches, predictors of good and bad therapy response must be clearly identified.
Thus reliable prognostic parameters differentiating high- and low-risk patients with stage Ta/T1 urothelial carcinoma of the bladder (Ta/T1 BC) might enable individual risk adapted follow-up regimes.
Primary outcome parameter was the efficacy of the risk adapted postnatal transmission prophylaxis regimen (two week oral ZDV in low risk patients).
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