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Soil residual N affected sunflower N accumulation and grain N content, both of which increased significantly with rising doses of N applied to the preceding wheat crop.
Gastrointestinal and genitourinary adverse events increased with rising doses.
In a like manner, the heamatocrit levels also decreased with the rising doses of oil, and were significantly higher in the control animals (45.78 ± 1.61%) with respect to test doses (Table 4).
This further adjusted regression model showed a statistically significantly increased risk at rising doses, meaning that increasing the dose can increase the risk of AEs by three times (OR 3.2; 95% CI, 2.7 to 4.0, p<0.001, figure 6).
The promising results of this experience led us to design the program-1 described in the present study in 1989, in which the induction phase with a combination of five drugs in rising doses led to a response rate of 89%, a result comparable with those obtained in other trials (Berthold and Hero, 2000; Pinkerton et al, 2000; Goldsby and Matthay, 2004).
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Based on these preclinical data, the cream formulation was chosen for single rising dose clinical studies, where plasma levels of MK-0873 were mostly below the LOQ, whereas skin biopsy concentrations ranged from 6.5 to 25.1 μM.
The chemicals were administered in drinking water during 30-60 daysubchronicic rising dose protocols.
Below the threshold, risk was unrelated to radiation, while above the threshold, it increased with rising dose.
TAK-438 was safe and well tolerated in multiple rising dose levels of 10 40 mg once daily for 7 days.
Phase I, a rising dose tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers.
LC3-I to LC3-II-conversion markedly increased with the rising dose of Mono-Pt over 24 h in Caov-3 cells (Fig. 4A and C).
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