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Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic.
Since APOL1 is involved in the resistance to infection by Trypanosoma brucei, the cause of African trypanosomiasis or sleeping sickness in sub-Saharan Africa [27], [28], there is a tantalizing possibility that a MYH9 risk haplotype in Africa has risen in frequency hitchhiking on the selective sweep of the nearby APOL1 gene.
The top two QTL are caused by presumably recent mutations on unique haplotypes that have rapidly risen in frequency in the population.
For example, a null mutation in APOC3 that had risen in frequency in the Amish founder population was found to be associated with a favourable plasma lipid profile.
Nonetheless, the power of most tests is strongly influenced by the timing and strength of the selective pressure; it has been suggested that the 602W allele has risen in frequency in some European populations as a result of natural selection, as its frequency seems to increase with latitude [ 35].
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Scientists studying climate change in this part of the world say they expect extreme weather, including cyclones and powerful tropical storms, to rise in frequency here.
Asthma and other allergies are thought by many experts to be rising in frequency because infantile immune systems, unchallenged by infection, are turning against the cells of the body they are supposed to protect.
Internationally, there has been much research into the health inequalities slope, whereby almost all important health problems gradually rise in frequency with increasing social deprivation.
An upcall is a contact vocalization that lasts about 1 to 2 seconds and rises in frequency, sounding somewhat like a deep-throated cow's moo.
Even now, we don't have a good understanding of either why appendicitis rose in frequency in the nineteenth century or why it fell through most of the twentieth.
Figure 6d shows the bursty-patch starting at the 8-min mark falling from 5 to 4 kHz for about 1 min, then rising in frequency to slightly above 5 kHz for the next minute or so.
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