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The Restoring Insulin Secretion (RISE) Consortium is testing interventions designed to preserve or improve β-cell function in prediabetes or early type 2 diabetes.
NIDDK has recently established the Restore Insulin Secretion (RISE) consortium to study approaches to maintain insulin secretion in adults and children with prediabetes or newly diagnosed T2D.
On the basis of the above rationale, the RISE Consortium will undertake exploratory studies to evaluate strategies to improve β-cell function, using glucose-lowering therapies (metformin, insulin, GLP-1RA) or obesity-reducing therapy (gastric banding surgery) in adult and pediatric participants with prediabetes or very early type 2 diabetes.
The RISE Consortium will provide critical information about the potential for early aggressive treatment approaches to lead to sustainable recovery of β-cell function in adults and youth after residual medication effects have dissipated and whether such approaches should be studied in larger clinical trials with longer follow-up times.
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