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Exact(6)
Twelve portals are placed around the ring, oriented toward each student's hometown.
Figure 4B shows the minimized structures of 7-keto-, 7α-hydroxy or 7β-hydroxy-DHEA with the A ring oriented towards the interior of 11β-HSD1.
Initial models of 7-keto-DHEA (with NADPH) and 7β-hydroxy-DHEA (with NADP+) with the D ring oriented towards the interior of 11β-HSD1 were constructed by using the Biopolymer option in Insight II for conversion of the 7α-hydroxyl to a ketone and to a 7β-hydroxyl, respectively.
Thus, we had six tertiary complexes of mouse 11β-HSD1 with 7-keto-, 7α-hydroxy or 7β-hydroxy-DHEA (Figure 4) for refinement by energy minimization using Discover 3. Figure 4A shows the minimized 3D models of 7-keto-, 7α-hydroxy or 7β-hydroxy-DHEA with the D ring oriented towards the interior of 11β-HSD1.
To obtain initial models of 7-keto-DHEA (with NADPH) and 7α-hydroxy-DHEA (with NADP+) with the A ring oriented towards the interior of 11β-HSD1, we used the Biopolymer option in Insight II for conversion of the 7β-hydroxyl to a ketone and to a 7α-hydroxyl, respectively.
However, the peptide tail folds over the macrolide ring, oriented toward the peptidyl transferase center and interacting in a novel manner with 23S rRNA residue C2442 and His69 of ribosomal protein L4.
Similar(54)
Docking of the most potent compound into the active site of human butyrylcholinesterase showed that the lowest energy model had two benzene rings oriented towards Trp 82 and Tyr 332 whereas the positively charged nitrogen group was stabilized by Trp 231.
The configuration D consisting of 37 transmitters is constructed by four rings such that each ring is oriented with different elevation angle, ranging from to with an angle interval of 30 degrees.
For the R stereoisomer, the styrene ring orients in the 5′-direction in the major groove, whereas for the S stereoisomer, the styrene ring orients in the 3′-direction.
The phenyl ring and indenopyridine rings are oriented by an angle of 67.8(1)˚ in compound (I) which is almost similar in compound (II) amounting the value of 55.2(1)˚.
However, (III) and (IV) attach to Pt(111) with their pyridine ring vertically oriented and N-attached, while the other aromatic ring is oriented parallel to the electrode surface.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com