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Additionally, nearly all of these projections contain a central ring of density from which the 10 radial arms extend.
At the threshold shown, the small ring of density in the map of full-length Hsp104 accounts for the expected mass of 6 Hsp104 N termini (110 kDa).
The O chamber is capped at the top by a ring of density with a small central opening of ∼20 Å in diameter while the IL chamber is widely open at the bottom with a diameter of ∼65 Å.
The N-terminal ring of density in the full-length Hsp104 map is linked with NBD1 by two connections, the stronger of which is at the position where the helix L3 end of the coiled-coil domain emerges, suggesting that the tip of the coiled coil interacts with the N-terminal ring.
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Methods Eighty one patients were ascertained who had a parafoveal ring of high density on fundus autofluorescence imaging.
A parafoveal ring of high density autofluorescence is a non-specific manifestation seen in different retinal dystrophies.
Most patients (n=39 eye; 81.3%) showed preserved central autofluorescence surrounded by a variable diameter ring of high density ('hyperautofluorescent ring' Figure 3, top row).
The internal edge of visual field constriction corresponded closely with the ring of high density, as shown by photopic FMM (Fig. 4d).
This study reviews a heterogeneous group of 81 patients with genetically-determined retinal diseases that manifest a common feature on fundus autofluorescence imaging in the form of a parafoveal ring of high density.
Some patients with genetically different forms of retinitis pigmentosa manifest a ring of high density AF representing abnormal parafoveal accumulation of lipofuscin which usually encircles preserved foveal areas [ 17– 20].
Results In patients with RP, the radius of the parafoveal ring of high density correlated with PERG P50 (R = 0.83, P < 0.0005, N = 62) and encircled areas of preserved photopic function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com