Sentence examples for ring modifications from inspiring English sources

In general, ring modifications (linearization or expansion) decreased activity towards all targets.

These central ring modifications help bacteria adapt to different levels of light.

Moreover, ring modifications in these ligands increase activity towards 5-HT1FR, 5-HT2Rs and 5-HT7R subtypes.

The most frequent replacements for self-bioisosteres are the following: halogen replacements (nearly 50%% of all substitutions), ring modifications, and substitutions.

All ring modifications of 5-HT1AR ligandecreasease the affinity for 5-HT1BR, 5-HT1DR and 5-HT1FR and 5-HT2R.

In the alternative pathway, the side chain oxidation of cholesterol precedes the steroid ring modifications, first yielding 24-, 25-, and 27-hydroxycholesterol metabolites, opposite to the process in the classical pathway.

The results of this study indicate that fixed ring systems have the potential to deviate from a pure moment loading state and that our novel sliding ring modification corrects this error in the original test design.

On the basis of this insight, 12 analogues of varying ring modification were taken, tested with LIE methodology and then validated with their experimental potencies of tubulin polymerization inhibition.

We can break down the lines of attack into three categories: Olympic ring modification; the mocking of Putin's macho preoccupation with his own bod, the typology also setting homo-erotic bells ringing; and finally, Putin's outright gay-ification.

From here, the respective biosyntheses branch, as Mg chelation, ring modification, methylation, ring oxidation/reduction, and substitutent modification result in a discrete family of chlorophyll and bacteriochlorophyll pigments.

MS/MS analysis showed that all heterocycles were thiazolines derived from Cys and clearly localized them to S C D C SLYGG C ES C, where C stands for thiazoline ring modification.