Sentence examples for ring modification from inspiring English sources

On the basis of this insight, 12 analogues of varying ring modification were taken, tested with LIE methodology and then validated with their experimental potencies of tubulin polymerization inhibition.

The results of this study indicate that fixed ring systems have the potential to deviate from a pure moment loading state and that our novel sliding ring modification corrects this error in the original test design.

We can break down the lines of attack into three categories: Olympic ring modification; the mocking of Putin's macho preoccupation with his own bod, the typology also setting homo-erotic bells ringing; and finally, Putin's outright gay-ification.

From here, the respective biosyntheses branch, as Mg chelation, ring modification, methylation, ring oxidation/reduction, and substitutent modification result in a discrete family of chlorophyll and bacteriochlorophyll pigments.

MS/MS analysis showed that all heterocycles were thiazolines derived from Cys and clearly localized them to S C D C SLYGG C ES C, where C stands for thiazoline ring modification.

We have demonstrated that the stereospecific S configuration of an α- tert-butyl group and the ring modification of a 5-OMe group are major determinants for creating a complete set of fast-cleaving reversible terminators with normalized rates.

Moreover, ring modifications in these ligands increase activity towards 5-HT1FR, 5-HT2Rs and 5-HT7R subtypes.

These central ring modifications help bacteria adapt to different levels of light.

In general, ring modifications (linearization or expansion) decreased activity towards all targets.

All ring modifications of 5-HT1AR ligandecreasease the affinity for 5-HT1BR, 5-HT1DR and 5-HT1FR and 5-HT2R.

The most frequent replacements for self-bioisosteres are the following: halogen replacements (nearly 50%% of all substitutions), ring modifications, and substitutions.