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In the case of boroxine ring dissociation enhancers, gels based on poly lithium-2-acrylamido-2-methyl-1-propanesulfonate) and ethylene carbonate poly lithium-2-acrylamido-2-methyl-1-propanesulfonate
The weak interfaces of the R R states are consistent with previous observations of ring dissociation in ATP (Burston et al., 1996; Ranson et al., 2001, 2006).
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As it has been already suggested by literature CD data [2], at this pH range, histidine contains a protonated imidazole ring, whereas dissociation occurs at the carboxyl and amine groups.
Ring, ring.
Cdc42 and its effector Gic1 are involved in septin recruitment, ring formation and dissociation.
Finally, based on our results we propose a novel regulatory mechanism for septin ring formation and dissociation involving Cdc42 and Gic1.
If cohesin associates with chromatin by encircling DNA, then release during prophase must involve ring opening due to dissociation of one of its three interfaces.
One possible trivial explanation for this lethality is that the cluster of neutralizing mutations reduces the affinity of half hinges, which according to the ring model would accelerate dissociation of cohesin from chromatin.
The two rings possess different acid dissociation constants, producing a net acid dissociation constant (pKa) of 8.0 8.5 (for overview, please see Hukkanen et al.[ 22]).
This dependence on protein concentration suggests that hPCNA unfolding is coupled to the dissociation of the ring.
Once established, cohesion is maintained, apparently without any cohesin subunit exchange [12, 13], from S phase until the onset of anaphase, whereupon cleavage of its kleisin subunit by a thiolprotease called separase opens the ring and triggers cohesin's dissociation from chromosomes [14, 15].
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CEO of Professional Science Editing for Scientists @ prosciediting.com