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β-scission of (cyclo alkylcarbenium ions is preceded by skeletal isomerization and ring contraction.
However, at high reaction temperature ring contraction to spirodecane and dehydrogenation to naphthalene were observed.
At 598 K, a maximum of 8% of ring contraction products was obtained.
An unexpected ring contraction of benzazepinone based αvβ3 antagonists led to the design of quinolinone-type derivatives.
This rapid rearrangement initiated with hydroxylation at carbon 14 followed by transesterification, resulting in ring contraction with formation of a butyrolactone at carbon-14.
More recent biochemical experiments have also demonstrated that the oxidative ring contraction during kinamycin biosynthesis is catalyzed by the flavin-dependent monooxygenase AlpJ19,20,21 and that hydrolysis of the epoxide moiety is catalyzed by the α/β hydrolase Alp1U3.
Similar(15)
The first approach, the analogical approach, consists of ring-chain transformations, ring contractions or expansions, and various other ring transformations.
Modifying ring systems ring-chain transystems ring-chainontransformationexpansions, and ringganization of contractionsms—represents andighly productivexpansions in the design of new drug andlogs and in the exploreorganizationdrug–receptof interacyclic.
By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred.' The vagueness is indicated by terms and phrases such as 'usually'oneore or more' and 'may have'.
Wang, B. et al. Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction.
The mechanisms involved in Z-ring contraction are unclear, but FtsZ assembly into the Z-ring is essential to cell division and crucial to the recruitment of other division proteins including FtsA, ZipA, FtsK, FtsQ, AmiC and EnvC [18], [19].
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