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Subsequent ring closing metathesis using 2nd generation Grubbs catalyst successfully generated novel class of ansa-compounds.
A novel 2-pyrrolidone synthase, ORF27, from Streptomyces aizunensis was identified to catalyze the ring closing dehydration of γ-aminobutyrate.
In metathesis pathway, the final ring closing metathesis step for benzene formation competes with another cross metathesis propagation step towards polyene chain expansion.
The dihydrothiopyran skeleton of 4 was constructed by the ring closing metathesis of 21 which was synthesized from but-2-yne-1,4-diol.
Rapid assembly of the core tricycle involved two key steps: Rh-catalyzed hydrogenation of an unsaturated bicyclic ring system and a Ru-catalyzed ring closing alkene metathesis reaction.
"There are many cracks in the ring closing tighter on Iran.
Similar(46)
Vinyl sulfone-containing macrocycles were synthesized via olefin ring-closing metathesis and evaluated against cruzain and the closely related cysteine protease, rhodesain.
Cyclizations were accomplished using ring-closing metathesis with the second generation Grubbs catalyst.
Macrocyclic olefin-containing lactones were also prepared by ring-closing metathesis.
A procedure for obtaining increased selectivity in a diastereoselective double ring-closing metathesis reaction is presented.
The key steps involved here are: Grignard reaction, double Claisen rearrangement, and ring-closing metathesis.
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