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Further study of the mechanism revealed that the introduction of a hydrocarbon ring altered the planarity of the chromophore as well as the binding affinities for G-quadruplexes, and therefore, influenced the ability to detect G-quadruplexes.
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The latter result was probably obtained when insertion of small rings altered or even destroyed the fragile macroporosity and also when using small rings increased the probability to only sample relatively homogeneous soil volumes.
Further, the binding of ssDNA to Rad52 rings altered Rad52 quaternary structure.
Thus, lack of tracheal rings altered proper differentiation of tracheal epithelium but not its proliferation.
In compound II, the substitution of Cl atom in the phenyl ring alters the configuration of carboxylate group with respect to the pyridine indane ring.
Intercalation of the tetracene ring alters local base stacking for the proximal base pairs but does not disrupt hydrogen bonding interactions.
Differences in the residues that underlie the Trp indole ring and altered interactions linking the 50′s loop to the active site suggested that reorientation of this ring may be disfavoured in the other six members of the FKBP domain family that bear this active-site tryptophan residue.
The position of the nicotinamide ring is altered slightly in the complexes of V203A ADH with either TFE or PFB because of puckering that brings NAD C6N 0.3 Å closer to 203 CA than in the wild-type enzyme.
Our hypothesis was tested by constructing mutants of DmTR using both conventional methodologies and protein semisynthesis, so that the C-terminal disulfide ring was altered in two different ways as illustrated in Figure 4.
Non-ring bonds altered during variable protonation processing are marked as non-stereogenic.
It has been already shown that the model initially proposed for explaining G6PD protection, by enhanced phagocytosis of ring- parasitized altered erythrocytes, fits well also in the case of HbS and β-thalassemia [20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com