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In a typical virtual screening campaign, the compound libraries are rigorously filtered to contain only drug-like molecules within a narrow range of chemical properties.
Our catalogue (Supplementary Table S2) was rigorously filtered ensuring estimated spectral false positive rates below 1% and minimal redundancy (see Materials and Methods for details).
In this article, we examine the proteomes of ten mammals by using four methodologically distinct, rigorously filtered OD methods.
These rigorously filtered data do show improved data quality, but at the expense of many measurements that could contain valuable information.
Following the study design in Figure 1, we first rigorously filtered the data at the mutation, patient, and tumor site levels to reduce the data noises and improve the predictive performance.
These were rigorously filtered (see supporting infromation) and 353,055 remaining reads (spanning 100,491,819 bases) were assembled using the combined assembler strategy [ 23], employing Roche 454 gsAssembler (also known as Newbler; version 2.6) and MIRA (version 3.21) [ 29] (Additional file 2).
Similar(54)
Superficially, there isn't an awful lot to separate Danny Dyer and Mick Carter – they're both cartoon cockneys in the classic mould – except the latter has been rigorously parsed and filtered to remove all the irritants.
The water was rigorously cleaned and filtered and treated before it was released, and it gets the same treatment again before it's piped to new customers.
Filtered selfies.
Filtered water.
Referees, however, have to make 3 or 4 decisions in each minute of the actual play time (Williams, 2013) and, thus, they benefit significantly from filtering visual information rigorously.
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