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"By contrast, Michael Adebowale was never more than a low level SoI {subject of interest] and the Agencies took appropriate action based on the rigorous threshold set down in law: they had not received any intelligence that Adebowale was planning an attack and, based on that evidence, more intrusive action would not have been justified".
The dissimilarity matrix was generated twice for pocket vs. pocket using a similar but more rigorous threshold, by expanding the binding pocket vicinity atoms to 6.5 Å, which should constitute a more difficult case than selecting a cut-off of 4 or 5 Å.
Both were subsequently given a more rigorous threshold detection evaluation.
This rigorous threshold was chosen with the primary goal of minimizing false positives when inferring function by similarity.
As a first step to connecting genes in a transcription network, a rigorous threshold is often applied to identify non-random correlations.
Permutation analysis (100,000) was used to determine a rigorous threshold for genome-wide significance accounting for multiple testing and for any unaccounted for systematic bias.
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Based on the rigorous thresholding, we assume that in our analysis the amount of vGLUT-IR in NG2 cells is underestimated.
Finally, the low number of the DVIs obtained was partly due to the rigorous thresholds applied.
Our SNP discovery pipeline called approximately 495,000 SNPs, although many more possible polymorphisms were detected before we applied rigorous thresholds for accepting a polymorphism.
Their usefulness notwithstanding, co-expression networks are prone to a high rate of false positive correlations arising from indirect relationships between genes, requiring that we establish rigorous thresholds and a layered (sequential) method (summary in Figure 1 and additional details in Additional file 1: sections A, C and D) [ 22].
We illustrated the loci of the portion of current distribution by a rigorous cutoff value of the z-transform of the difference vector between conditions (but also inspected results after a non-rigorous threshold), for the attention-related frequencies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com