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NEXT-peak is based on rigorous statistics, so its model also provides a principled foundation for a more elaborate statistical analysis of ChIP-seq data.
It is only on the basis of rigorous statistics that the two groups believe their snips must be causally associated with heart disease.
Few reviews used meta-analysis or other rigorous statistics that permit assessment of outcome sensitivity to influential observations; in general, review protocol descriptions were not sufficient to ensure transparency and appropriate handling of common biases.
It has been suggested that a considerable portion-perhaps as much as 20%-of all fungal sequences deposited in INSD may be incorrectly annotated to species level [8], though rigorous statistics are lacking.
These results show that exact motif discovery based on rigorous statistics, although still a considerable computational burden, now lies within the reach of today's computers.
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Although the analysis was conducted according to our current methodological standards using rigorous statistical evaluation, statistics are not always the only relevant factor in real-life individual patient management; clinical judgment, assessing the likely risks and benefits of each proposed strategy, also plays a role.
These maps represent evidence-based estimates of the current global distribution of the leishmaniases incorporating a comprehensive occurrence database and a rigorous statistical modelling framework with associated uncertainty statistics.
Higher ranked assessments of validity and reliability were also characterized by more rigorous statistical comparisons, including the use of sensitivity and specificity measures [ 15], kappa and other statistics [ 16] or other statistical comparisons [ 17].
Following our recently proposed information PDC and information DTF [5], and their corresponding rigorous asymptotic statistics (see [3] and [4] for details), we first gauged their statistical performance against that of the well-established time-domain GCT test [2].
Wanting to make the analysis even more rigorous, FORBES statistics editor Scott DeCarlo and I took Munos count of drug approvals for the major pharmas going back 15 years and combined it with their research-and-development spending over that same time period, as culled from Thomson Reuters according to FactSet Research Systems.
We bring together rigorous motif statistics and motif discovery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com