Panviral microarrays are useful for broad surveillance of bloodborne pathogens (9 ), yet rigorous individual probe validation across multiple targets is needed because of potential cross-hybridization artifacts.
Three new books approach the mystery from distinctly different perspectives: the unlikely believer in UFOs, the visionary dedicated to rigorous investigation and the cadre of scientists who still plug away at the problem, probing the universe for an answer.
My viewing has been less than complete, but I doubt I've missed any rigorous journalistic probing.
Note that the filtered set of B>M probes provided substantially more benefit for Method II than for Method I. Consequently, rigorous filtering of probes is more critical when using a single hybridization (Method II) than when data from multiple hybridizations (Method I) are available.
For all the sheer energy of the music-making, here was a probing, rigorous and richly characterized interpretation, which Mr. Dudamel conducted from memory.
Within the constraints of the technology (70-mer probes versus 25-mer probes), this sequence-based probe-to-probe mapping is the most rigorous method of identifying comparable matching probes to assess inter-platform reproducibility.
This probing and rigorous account will provide answers to these often asked questions -- Provided by publisher.
"Judges must be alert to the point and must be rigorous in exploring and probing local authority thinking in cases where there is any reason to suspect that resource issues may be affecting the local authority's thinking".
The approach described above allows a rigorous separation of N probes of processes I and III and we have used a similar procedure for methyl-C probes.
When applied to the wild-type and cli186 dataset over all 24 comparisons (3 treatments × 2 replicates × 2 controls = 12 treatments for each genotype × 2 genotypes (wt and mutant) = 24 comparisons), these rigorous filtering steps removed probes corresponding to 21,186 genes, leaving 1,624 genes that showed consistent reliability for further analysis.
In order to minimize the total number of probes while covering as many families as possible across a phylogenetically diverse set of organisms, we developed rigorous algorithms to choose conserved probes that ensured detection of divergent sequences within a family.
