The primary endpoint was annual change in TKV, which was lower with rigorous blood pressure control than with moderate blood pressure control (P = 0.006).
The importance of rigorous blood pressure control is recognized in current guidelines, with a recommended target of office blood pressure of < 130/80 mmHg; although ambulatory blood pressure may be more appropriate in order to identify the 24-hour hypertensive burden.
The study aimed to test the hypothesis that rigorous blood pressure control was more effective in slowing progression of renal disease in early ADPKD than moderate blood pressure control, by comparing the combination treatment to ACEI monotherapy alone.
Implications of this rigorous disjoining pressure model on the thermo-physics of thin film evaporation in a kinetically controlled limit are investigated in details, and contrasting confluences as compared to the traditional descriptions of the disjoining pressure are emphatically pinpointed.
Tumor cells may display additional vulnerabilities, and possibly strengths, that reflect the natural history of their evolution in the host that are not seen in cells that have been transformed in tissue culture, where they have not been subject to such rigorous selective pressure.
However, by 1940, as a result of rigorous regulation and pressure from unions (the subway workers union was a closed shop) the different subway lines were taken over by the city and over the years the prices rose outrageously (always in need of government subsidies) as the service declined dramatically.
Our findings raise the question as to whether early and rigorous arterial blood pressure resuscitation could reduce neuronal loss in traumatic brain injury.
The conservation equations impose a rigorous constraint on the pressures on the control volume, that they balance the sum of all other forces acting on the CV.
Ultimately, control volume formulations of CSF and blood flow in the brain may be performed as a scientifically rigorous means of quantifying pressure variations throughout the brain.
This highlights the fact that, as previously demonstrated for filling pressure a rigorous technique for PPV measurement is of particular importance [ 50].
