This allowed a rigorous loss-of-function examination of any possible role of this E3 ligase during embryogenesis and with biochemical analysis and reporter assays in isolated MEFs under in vivo conditions.
The average overall efficacy of an unsupervised rigorous weight-loss program is about 20 kg/year.
Growing evidence exists for the benefits of peer support [ 26] but, like other types of support interventions following perinatal loss, rigorous evaluations of the contribution of peer support to psychological outcomes following the death of a baby are scarce [ 27].
This paper proposes a methodological approach to evaluate and integrate, in a consistent and rigorous way, the economic losses as a function of the seismic hazard intensity for prototype building constructions.
To the Editor: Is John Tierney actually giving a thumbs up to low-carbohydrate diets by touting one recent "rigorous" study showing "better" weight loss results?
Thus, rigorous conclusions of for example, loss of activity or hyperactivation of CLEAs respect to native enzyme, can be drawn.
The BBC study, for example, was a rigorous trial comparing several weight loss plans.
This work is an attempt at creating a rigorous "null" model of duplicate loss, based on parameters μ, ϕ and θ.
Our use of flow sorted samples allowed objective discrimination of homozygous loss with a rigorous threshold of log2ratio < -3.0 in our aCGH results.
A multi-modal contact strategy, such as mail followed by telephone calls, and making repeated contact attempts, as done in this study, is typical of rigorous approaches for minimizing participant loss to follow-up and associated missing data [ 19– 219.
"Each transaction guaranteed by MBIA needs to pass a rigorous underwriting process proving no losses will arise under the worst probable case scenario," the company said in a typical investor presentation just three years ago.
