Instead, we feel the most rigorous and quantitative indication of LPS shedding is the measurement of LPS in culture supernatants we performed.
We found that, in the case of new "family members" (i.e. new surgical devices made by a manufacturer who already produces licensed devices for the same clinical indication), rigorous evidence of safety is not required for MDB to license the new device, even though the use of such a device may be potentially harmful to patients.
17 These findings may well be an indication of more rigorous reporting requirements in these journals.
This study is intended to provide a rigorous validation study and gives important indications on the errors committed by these methods in solving more complex geometry and dynamics, where usually many sources of errors are interplaying.
Despite these positive indications of attitudinal change, rigorous evidence on the extent to which male engagement programmes can shift behaviours and social norms is less conclusive (Fulu, Kerr-Wilson, and Lang 2014; Jewkes, Flood, and Lang 2014).
This indication for He/O2 has never undergone rigorous investigation in a large randomized trial because of the considerable heterogeneity in patients and technical problems.
There is a growing list of potential indications, although many applications still await evaluation in rigorous clinical trials [ 4].
To decrease IC incidence, human and material resources must be optimised and the indications of invasive investigations and monitoring must be more rigorous.
The pilot study not only provided a rigorous test of the phenotyping procedure but also offered an indication of the range, severity and penetrance of individual abnormalities that can be readily identified from HREM data.
Although it is recognized in many of these areas larger and more rigorous trials must be performed, this paper hopes to give some indication of areas in which further research is warranted.
