Markov chain Monte Carlo Bayesian estimation offers a robust and statistically rigorous approach for incorporation of prior information into mechanism-based models.
Second, incorporation of rigorous independent, blinded, centralised outcome review with strict assessment guidelines in the current studies may have impacted the rates of determined response (Dodd et al, 2008).
Furthermore, the implementation of coverage of additional chemical concepts in most chemical representations requires a formal, rigorous representation specification, complicating the incorporation of data represented using domain-specific representation extensions.
These measures include screening of blood donors, rigorous testing of plasma pools, incorporation of virus inactivation or removal steps into the manufacturing process and ultimately, the development of recombinant products [ 83].
The formal incorporation of scientifically-rigorous monitoring guidelines into forestry management plans, and into the criteria of FSC and other timber certification schemes, is an important step in evaluating the benefits of these policy measures for wildlife.
Effort is put on the construction of a consistent and rigorous thermodynamic framework, which readily allows the incorporation of non-local features into the constitutive modelling.
We employed a rigorous study design that included randomization of samples across experimental variables, incorporation of precise individual measurements of exposure, and analysis with a mixed-effects model, with the aim of removing sources of biological and experimental variability (nuisance variability).
10 However, despite widespread adoption and incorporation of liver RFA into modern multidisciplinary management of liver cancer, more rigorous controlled trials are warranted to further elucidate its role in prolonging patient survival.
Improvement of individual patient predictive-ability might be achieved by incorporation of additional biomarkers into a predictive model that could be subjected to rigorous confirmatory studies in larger patient cohorts treated with anti-TNFα and anti-IL-6/IL-6R blocking agents including combination treatment with methotrexate, with incorporation of prespecified cutoff values in the analysis plan.
The incorporation of such multiple functions is complicated, requiring exquisite chemical control during production and rigorous characterization studies to confirm the compositions, structures, properties, and performance.
