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Rigorous efficacy studies are next.
30 A recent Cochrane Review highlighted the small number of rigorous efficacy studies currently available in the literature on the effectiveness of acupuncture in treating sleep disturbance.
By performing rigorous efficacy, pharmacokinetic and toxicity studies using a number of different lymphoma mouse models the preclinical evaluation of G3139 was completed and further studies were extended into a phase I study for lymphoma patients with high Bcl-2 expression.
The generalisability of the available evidence for efficacy of BPTs to LMIC settings may be limited by the narrow representativeness of the study populations in the most rigorous efficacy trials, most of which were drawn from high-income (mostly English speaking) countries.
Rigorous efficacy evaluations and expanded risk assessments of adopted mitigation strategies to protect public and animal health are needed to help animal and public health experts make evidence-based recommendations for reducing intraspecies and interspecies transmission of influenza A virus in this setting.
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Some of the acute trials apply even more rigorous primary efficacy endpoints, such as "pain free at 30 min" [82] or "total symptom relief at 1 h" [59].
A spokeswoman for Johnson & Johnson, which owns Piz Buin, said: "Our products are subject to rigorous safety and efficacy testing; in the case of sun care products, this includes SPF testing in line with the EU sun care recommendation".
As a departure from traditional treatments, gene therapy approaches provide a new hope for realizing this long-sought goal; but before they can be widely employed for use in patients, they must first be submitted to the rigorous safety and efficacy standards of the clinical trial.
This off-magnet confirmation allowed us to conduct an independent, rigorous test for efficacy of our backward-masking procedure, without impacting the critical design feature of the imaging experiment – to determine the brain response to an uninterrupted flow of stimuli during natural, passive viewing, without the interruptions and potential confound of task demands/performance concerns.
While most CAMs are tested for safety, rigorous tests of efficacy are scarce [ 41, 42].
Less rigorous data suggest efficacy in traveler's diarrhea, relapsing Clostridium difficile-induced colitis, and urinary tract infections.
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