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The Common Rule, WHO guidelines, and consensus statements have sought to distinguish research and QI based on the rigor of methods (internal validity) and generalizability (external validity) of the findings [ 4– 6].
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In evaluation as it has been practiced, requirements for specialized training have caused a trade-off between rigor of method and the extent of program staff's involvement in the evaluation process.
Defining the intended application of the biomarker (for example, will it be used for internal decision making, exploratory research, or as a diagnostic) will determine the rigor of method validation and assay documentation needed.
Given the rigor of quantitative methods and the subjective information gained through qualitative inquiry, the use of mixed methods is increasingly common in the assessment of HRQOL [ 51].
One teacher there, the composer James Tenney, became a significant mentor, his wild imagination balanced by the mathematical rigor of his methods.
Finally, based on the rigor of the methods we followed, we trust that teachers in our interview study responded honestly to the questions asked.
The Warrens, for their part, are somewhat straitjacketed by the rigor of their methods.
Scientists constantly evaluate each others' work, questioning the rigor of the methods, the strength of evidence in conclusions, and looking for articulation of uncertainty.
Moreover, despite all the rigor of statistical methods, for many risk domains, such as cyber and reputation risk, the data set is shallow and largely unreported.
We believe the consistent statistical significance in both analyses demonstrates the rigor of our methods.
Inter rater reliability is adequate, lending support to the rigor of our methods.
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