It is predicted that at high strain rates, most of SSr and part of SSm would become rigid, resulting in dynamically induced strengthening and toughening.
The increase in membrane fragility can be attributed to the formation of these large ceramide-enriched membrane platforms, as earlier studies revealed them to be very rigid, resulting in a weak interface between the platform and the surrounding plasma membrane.
To achieve the best possible non-rigid results, the distortion-corrected frames of the first iteration are reused to create a new reference image and the process repeated.
The curved shape of the rigid shell results in gross deformation and load spreading.
Therefore, for simplification, the comparison between the various programs was solely based on the rigid docking results, with one scoring function, Goldscore for Gold, G-score for Glide, and the eponymous Surflex and FlexX.
For the flexible docking, and based on the rigid docking results, Surflex offers the opportunity to slightly minimize the potential energy of the side chains of the protein binding site in the presence of the docked compounds, in order to refine and rescore the docking pose.
In brief, we first applied a distance cut-off, based upon our rigid docking results for protein structures 2CN5 and 2W0J, to include all protein residues of the respective ligand-binding site with the potential to be treated as flexible.
The higher dimerization rates of more rigid tiles results from the opposing effects of higher activation energies and higher pre-exponential factors from the Arrhenius equation, where the pre-exponential factor dominates.
This allows the use of a control design solely based on rigid dynamics, resulting in a low-order control solution, for which coverage is demonstrated by means of multivariable robust performance and stability margins expressed in the structured singular value metrics.
This result is consistent with that reported on 3-phenyl COE, suggesting that bulky and rigid substituents result in lower polymerization rate.
The semi-rigid approach results in more economical solutions.
