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Three impediments in particular work against agile in most organizations: rigid architecture, poor talent management, and lack of a product mindset.
The ZN-1 domain, when associated with Zn2 +, assumes a rigid architecture that is stabilized by thiol groups from the residues C159, C176 and C179.
The rigid architecture and size of ESCRT-I and ESCRT-II (see below) may help to stabilize the bud neck of a growing vesicle.
These are small peptides, typically ranging from 30 to 40 residues in length, held together by three or four disulfide bonds in a rigid architecture.
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Current rigid architectures can provide high performance, but they hardly support network design flexibility.
Some are too reliant on technology tool kits and rigid architectures, and not enough on creating the right environment to effectively leverage people with the right expertise to drive D&A projects forward.
This departure from monolithic rigid architectures provides the space systems with more flexibility and robustness in response to uncertainties that the system confronts during its lifetime.
Herein, the octavinyl POSS acted as not only the building blocks for hybrid rigid architectures but also the cross-linker for the formation of effective recognition sites during the imprinting process.
A fundamental question is therefore whether the neural activity underlying this non-rigid architecture is language-specific, given that analogous structural properties can be found in other cognitive domains.
Together, our results suggest that NRPSs lack a uniform, rigid supermodular architecture.
That same insight is at the core of the rigid comic architecture of Fernanda Coppel's "Chimichangas and Zoloft," an energetic, overstuffed play about girls growing up fast while their fathers strain to recapture their youth.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com