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During the reign of Elizabeth, as part of a developing system of monopolies, the former short-term privileges for publishing certain works or classes of works (called "copies") were granted, for a consideration, as life patents with rights of reversion, such as those enjoyed by Richard Tottel for law books or John Day for alphabet books and catechisms.
Outside government, the debate has the same quality of reversion to form, as opposed to engagement with the problem.
Some of the decline in approval ratings, then, is a case of reversion to the mean.
There is lots of reversion to the mean for both winners and losers.
The next question: What is the rate of reversion to the mean?
Finally, you can use the process of reversion to the mean to your advantage.
In our case of reversion events, tree vertices represent a reversion at a specific codon and edges are associated with the conditional probability that a reversion will occur, given that the ancestor in the tree has occurred.
Notably, the mutation K103N had a high rate of reversion at both timepoints, with a reversion rate of 62% over the duration of the STI.
The rate of reversion of Y181C increased from 9% to 33%.
Of course, the rate of reversion could differ between different antiretroviral drug-based mutations.
More research is needed to understand fully the mechanisms of reversion to wild-type off therapy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com