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Such sequence specificity endows RuvC with an added level of substrate selectivity since efficient cutting is only achieved if both active sites within the homodimer are correctly positioned next to a strand with the right nucleotide sequence.
Amino acid distances are shown on the right, nucleotide distances on the left as determined by MEGA Vers.
One state acts as the main state, that is, for example, each pair (P) node has a pair state matching both a left and a right nucleotide.
They have even been called specialized polymerases because they are able to insert the right nucleotide across from the damaged one.
Based on the recently re-annotated gene table of E. coli K12 genome [ 23] these genes have the following coordinates, yaaW [UniProtKB P75617] and htgA [UniProtKB P28697] (yaaW: locustag K-12 ECK0011, left nucleotide 10643, right nucleotide 11356, direction of transcription ; htgA: locustag K-12 ECK0012, left nucleotide 10830, right nucleotide 11315, direction of transcription.
In fact, TLS can be further divided into two sub-branches: the "error-free TLS", taking place when Pol- η incorporates the right nucleotide opposite a CPD, and the "error-prone TLS", occurring when Pol- η incorporates a wrong nucleotide opposite a 6-4 PP and then stalls.
Similar(54)
Altering enough of the right nucleotides at once could eliminate the specific sequences that viruses need to reproduce, but still produce the necessary proteins required for that person's well-being.
bValues above the diagonal and the right show nucleotide identities; those below the diagonal and to the left show amino acid identities.
bValues above the diagonal and to the right show nucleotide identities; those below the diagonal and to the left show amino acid identities.
Let S′ be the oligomer in which the right-most nucleotide is removed from S. We define the equiprobable oligomer S such that it has the following property, (3) where θ is a threshold parameter.
It was found that the seed regions of all the species were conserved, while one nucleotide right behind the seed region was changed from U to G and another one was deleted in cis-miR-7 of miR-7 family.
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