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We found that RIG-I was extensively ubiquitinated and REUL expression markedly increased the ubiquitination levels of RIG-I.
retinoic acid-inducible gene-I (RIG-I -like RIG-I -like
While binding viral RNA, LSm14A colocalizes with RIG-I-MAVS and activates IRF3 through the RIG-I-MAVS signaling pathway.
Its relationship to RIG-I is unknown.
Moreover, this IFNβ activation also appeared to depend on RIG-I, as a dominant-negative form of RIG-I (RIG-I-ΔCARD) inhibited this response.
LFG mostly affected RIG-I-like receptor signaling pathway.
These ssRNAs are recognised by the helicase RIG-I.
Interestingly, shR9 bound RIG-I migrated as two distinct bands.
Interestingly, studies aiming to characterize RIG-I polymorphisms are scarce.
We used a cell-based RIG-I dependent luciferase reporter assay to identify modulators of RIG-I signaling.
It is therefore possible that S183I SNP inhibits downstream signaling by altering RIG-I oligomerization or RIG-I/MAVS interaction.
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