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The range of mean population densities and the slope of the rif plus phage treatment resembled those of the phage (alone) treatment far more than those of the rif (alone) treatment.
Micobactericidal activity of RIF alone or in combination with DODAB.
Table 4 showed MBC for RIF alone or in combination with DODAB.
We use this model to generate a repository of in silico granulomas and then "treat" these granulomas with isoniazid (INH) and rifampin (RIF), alone and in combination.
However, this action of RIF alone is not sufficient to increase lifespan as RMN having similar DAF-16 activating property failed to positively affect longevity in wild-type worms.
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The ability of RIF resistance alone to predict MDR was also investigated.
Novel technologies for rapid detection of anti-TB drug resistance have therefore become a priority in TB research and development, and molecular line probe assays focused on rapid detection of RIF resistance (alone or in combination with INH) are now commercially available.
A dose-ranging study comparing RIF and rifapentine (RPT), alone and in combination with first-line drugs, did not demonstrate any significant differences in drug efficacy between C3HeB/FeJ and BALB/c mice (Rosenthal et al., 2012).
Recall that, while both strains KZN-V2475 and KZN-R506 are resistant to INH, RIF, and STR, KZN-R506 alone is also resistant to kanamycin and ofloxacin.
From 292 drug resistant isolates, 215 isolates were RIF resistant, but only 17 samples were RIF mono-resistant.
Bacterial populations treated only with rif showed a very high slope (5.43), whereas populations exposed to rif plus phage showed a relatively low slope (1.51).
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