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Experiments provide evidence that our approach helps team participants to build richer domain models than if they do not use our software tool.
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PPDMs provides a richer, domain-level perspective of small molecule binding and enriches annotation of small molecule bioactivities stored in the ChEMBL database.
Cysteine-rich domain.
proline-rich domain.
Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonine-rich domains and a proline-rich domain.
The KS-rich domain lies adjacent to the G2 region.
G1, G2 and G3, globular regions; IGD, interglobular domain; KS, keratan sulfate-rich domain; CS1 and CS2, chondroitin sulfate-rich domains.
On the intracellular side, ROR1 possesses a tyrosine kinase domain (TKD), two serine/threonine-rich domains (Ser/Thr), and a proline-rich domain (PRD).
The KS-rich domain is followed by the chondroitin sulfate (CS -rich domain, whiCS -richvidomainto twhichbdomaiss (CS1 andividedthat dintor in amino acid sequence.
SPP, pro-rich domain containing the Ser-Pro-Pro (SPP) motif.
We generated a mouse encoding p53 lacking the proline-rich domain (p53ΔP).
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