Toh et al. [ 9] reported a new mechanism by which ∆Np73-β, but not α, could activate the transcription of the pro-survival caspase-2S through a GC-rich specificity protein (Sp1 -binding Sp1 -bindingpromoter, a mechanisitelso used by the TAp73 inoforms [ 9, 11].
Those visiting loved ones tell the best stories, rich with specificity, surprise and emotion.
SERS combines the extremely rich structural specificity and experimental flexibility of Raman spectroscopy with the tremendous sensitivity provided by the plasmonic nanostructure-mediated amplification of the optical signal (Le and Etchegoin 2009; Schlücker 2014).
Maud, awakened to her fascination with the uncharted, makes for the open sea, and her hazardous solo voyage on the Atlantic is the book's centerpiece, evoked by Miller with rich and detailed specificity.
Thus, peptides, aptamers, and phosphate-rich compounds with specificity toward proteins, cells, and molecules within the regenerative bone microenvironment may enable the design of targeted carriers with bone biodistribution greater than that achieved by drug alone.
Fbs1 is known to bind mannose rich polysaccharides without any specificity concerning amino acid sequence.
It is difficult to design assays in CpG-rich areas without having the probe overlapping flanking CpGs, and with the probe having sufficient annealing temperature to achieve robust annealing and specificity in the highly AT-rich sequence after bisulfite conversion.
An acidic residue binding to the 2′ and 3′ hydroxyls of the adenine ribose and located downstream of the Gly-rich motif confers NAD(H) specificity, whereas NADP(H) binding is dictated by the presence of a basic residue within the Gly-rich segment.
He is implicated in one of the film's richest ironies: after all its specificity about racial matters, we arrive at Ellington, who mostly refused to talk about race.
For example, seco-CI-InBf (5a) and seco-CI-TMI (5c) demonstrated specificity for AT-rich sequences, particularly by reacting with the underlined adenine-N3 position of 5′-AAAAA 865 -3′.
Finally, in more complex matrices characteristic of biological fluids or organic matter-rich natural waters, the increased specificity of analysis by ToF-MS allows for greater discrimination from matrix that can potentially complicate the use of some UV or fluorescence-based detection methods.
