Broadly speaking, these were (EPC1) from long, polar, high-O content proteins to aromatic, high-C proteins; (EPC2) from hydrophobic, high-GC proteins to positive, high-N proteins, (EPC3) from more polar proteins to more negative, more hydrophobic proteins and (EPC4) from GC-poor, S-rich, aromatic proteins to GC-rich, positively charged proteins.
The BR motifs are rich in positively charged lysines.
This domain is rich in positively charged amino acid residues, which may contribute to DNA recognition and binding.
The primase binding surface of NTD of BstDnaB is exclusively covered by negatively charged side chains at center that must be aiding a strong binding with the CTD of BstDnaG, which is rich in positively charged side chains on the of helicase binding surface.
Analysis of the surface charge distribution of the yeast eIF3b-RRM revealed a high degree of similarity to its human homolog with the surface made up of two α-helices packed against the β-sheet is rich in positively charged residues, creating an overall basic region distal to the accessible surface of the β-sheet (Figure 3A B).
The core histone N-terminal domains are rich in positively charged basic amino acids, which can actively interact with DNA.
Among which three unique segments rich in positively charged amino acids were denoted as putative HBRs including RWRCK (HBR1), RSRFR (HBR2), and RPGRRR (HBR3).
It is also known that APP has a heparin-binding site in its extracellular region, which is thought to be rich in positively charged amino acids.
Most CPPs are rich in positively charged Arg and Lys residues and are internalized after initially interacting with cell surface negatively charged GAGs which cluster CPPs on outer membrane surfaces [ 9, 10].
The conformation of M2-1 may be further affected by the use of high pH, as the interface is rich in positively charged residues with a total of eight arginine or lysine residues.
