Finally, we determined that both isoforms of the AT-Rich Interacting Domain 4B (ARID4B) protein could induce G1 arrest when overexpressed.
We used our vectors to demonstrate that a protein of interest can be overexpressed or depleted in mitotically-arrested cells, generate stable cell lines where the senescence secretory associated phenotype (SASP) can be induced, and show that the chromo domain of the AT-Rich Interacting Domain 4B (ARID4B) protein is not required for the G1 arrest upon overexpression.
Enrichment of the Hippo pathway components with WW domains and their cognate proline-rich interacting motifs provides a versatile platform for further understanding the mechanisms that regulate organ growth and tumorigenesis.
It's very bad, about the Hamptons (I think?) and a less-rich person interacting with a cosmos of rich people and rich people things.
But the visuals are so rich, and interact so provocatively, that you may well be inspired to go out and do some homework and come back for a second look.
Open image in new window Figure 2 Both the three zinc fingers and RRK rich motif interact with RBBP4.
In this work, we found the molecular basis of AEBP2 RRK-rich motif interacting with RBBP4, which shares the same binding interface with histone H3 and is relatively smaller.
The upstream domain contains a decoy 3' splice site, highly similar to an authentic 3' splice site, and a downstream domain with U/C-rich repeats interacting with polypyrimidine tract binding protein, PTB [9], [10].
RydC (orange) sits on the proximal face of Hfq, with the 3′-end U-rich tail interacting with the central channel and the two conserved U U pairs (U23/U24 and U46/U47) making contacts with the lateral face of the hexamer.
The proline-rich domain interacts with SH3 domain proteins of Src and Grb2.
A crystal structure of the Rna15 RRM–Hrp1–RNA complex showed that the A-rich RNA interacts with the surface of the RRM β-sheet, which is the canonical mode of RNA recognition for RRMs.
