Sentence examples for rich conformation from inspiring English sources

NADH caused a transition of RSP from an α-helix rich to β-sheet rich conformation.

Its ability to aggregate irreversibly through formation of a β rich conformation mimics the behaviour of at least two of the nine known proteins linked to polyQ diseases.

In summary we documented a novel active immunization approach using pABri in a β-sheet rich conformation that targets an abnormal conformation that is shared by aggregated/oligomeric Aβ and PHFs.

A step into this direction may be represented by the study of Chakroun et al. [14], whereby the structural properties of the isolate α2-α3 region, which recapitulates the amyloidogenic features of the whole protein and contains the mutations herein studied, have been elucidated by means of MD, generating a as the isolate β-sheet rich conformation consistent with experimental observations.

The current studies demonstrate that recombinant PrP in its fibrillar β-sheet rich conformation subjected to annealing induces a transmissible form of prion disease in wild-type animals.

The protein only hypothesis proposes that prion disease is associated with the misfolding of the normal cellular prion protein (PrPC) into a more protease-resistant, β-sheet rich conformation (PrPSc) [ 1], which can be induced by infection with exogenous PrPSc, spontaneous accumulation of PrPSc, or genetic mutations in the prion gene (PRNP) [ 2].

To date, attempts to generate transmissible prion disease in wild-type animals using rPrPs have not been successful despite numerous attempts in which rPrP was converted into a broad array of abnormal β-sheet rich conformations.

This copolymer was found to have a highly alternating and stereochemically atactic sequence and a predominantly trans-rich conformation about the main-chain methylene-methine bond in deuterated dimethyl sulfoxide solution.

The presence of SDS at higher concentrations (e.g., 0.25, 5.00, or 20.00 mM SDS) was found to suppress fibril formation of lysozyme whereas fibrillogenic lysozyme SDS ensemble containing β-sheet-rich conformation was observed upon the addition of lower concentrations of SDS (e.g., 0.00, 0.06, or 0.1 mM SDS).

This fact indicates that the PVA molecular chain aggregates containing the PVA iodine complexes should be composed of PVA segments with the trans-rich conformation and the PVA iodine complexes therein may also be formed with these several trans-rich segments surrounding the rod-like polyiodine cores in agreement with the so-called aggregation model.

Hsp104 rapidly solubilizes the unusually stable β sheet-rich conformation of NM fibers.