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Atrial fibrillation, irregular rhythm of contraction of the muscles of the atrium, the upper chamber of the heart.
Some involuntary muscles are spontaneously active, and the action potentials in their nerves only modify the natural rhythm of contraction.
We previously demonstrated that bile acid taurocholate (TC), which is raised in the bloodstream of ICP, can acutely alter the rate and rhythm of contraction and induce abnormal calcium destabilization in cultured neonatal rat cardiomyocytes (NRCM).
DOI: http://dx.doi.org/10.7554/eLife.04801.001 The heart is a large muscle that pumps blood around the body by maintaining a regular rhythm of contraction and relaxation.
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This restores rhythmic calcium ion cycling in the cytoplasm and enables the heart muscle cells to develop regular rhythms of contraction and relaxation.
Previously, we hypothesised that raised fetal serum bile acids in ICP cause fetal arrhythmia and sudden intrauterine death and demonstrated that TC can acutely alter the rate and rhythm of cardiomyocyte contraction and cause abnormal Ca2+ dynamics of single cells[11].
This resulted in an equivalent expression " to follow the rhythm of the contractions", which is more common in the Swedish culture.
The scanning ion conductance microscope (SICM) provides accurate measurement of the rate, rhythm and amplitude of contraction on NRCM.
One of the good IRI models is cardiac surgery in which reperfusion may cause deterioration of rhythm and contraction of myocardium.
To evaluate whether the observed abnormal contraction rate defect reflects irregular rhythm, abnormal contraction signal propagation, or uncoupling of atrial from ventricular contractions, we developed a method of optical digital cardiography (DCG) for in vivo quantification of heart function in zebrafish.
We have also demonstrated the functional importance of the local clock activity by providing the first evidence for circadian rhythm of receptor sensitivity in smooth muscle contraction.
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