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Autophagy is a survival pathway classically associated with adaptation to nutrient starvation [ 23] and, as UPR, autophagy presented a diurnal rhythm of activation in rodent liver [ 24, 25].
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In the double mutant, PRR9 showed a lower amplitude rhythm, probably because of the loss of activation of expression by CCA1 and LHY.
In the rostral rhythm, KE activation follows that of HF, here represented by the activation of ER, with a delay.
Even though the authors report inhibitory actions of GABA at all times explored, they describe that GABA pulses induce phase shifts in the circadian rhythm of the extracellular SFR (through the activation of GABAA R) of single SCN neurons, in cultured slices.
In a successful pocket rhythm, KE activation can occur at any value of (s_{mathrm {dynamic}}=s_{mathit {ER}} in I_{s}).
Therefore, the incapacity of these schedules to produce hypersensitivity might be due to a long time infusion rather than to failure of activation of the immune system (which presents a circadian rhythm) in a chronomodulate setting (Levi et al, 1994a).
It remains to be determined whether the paracrine signaling peptides that restore rhythms act to enable orderly progression of oscillation of distinct clusters, i.e. the sequence of activation of clusters is carried by a peptidergic temporal code.
The revised DSM-V criteria recognize the importance of activation as a cardinal feature of bipolarity, which is often a manifestation of underlying circadian rhythm dysregulation [ 40, 41].
Third -- and this is probably interesting to neuroscientists -- among brain regions associated with complex social behavior, we observed a mix of activation and de-activation.
Alternative accounts of activation or arousal exist.
(Transcriptional activation is a kind of activation).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com