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Required textual revisions: 1) Please revise the text to make it as clear as possible how much residual AP2 function may exist in the hemi knockouts.
Essential revisions: 1) Please revise the manuscript to provide more focus on the major conclusions and message and a clearer, more streamlined description of the experiments and data.
Specific revisions: 1.
I do have some suggested revisions: 1.
Essential revisions: 1) Better define darting and darters.
Essential revisions: 1) Prazosin is an alpha1 specific antagonist.
Essential revisions: 1) The dose response analysis needs revision.
Essential revisions: 1) Compare Yan-YFP to endogenous Yan.
Essential revisions: 1) The expert reviewers were concerned about how the reset coding proposed might work.
Essential revisions: 1) The experiments testing differentiation capacity to renal lineage are not entirely convincing.
Essentials revisions: 1) Most of the studies presented are based on Spire1C over-expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com