The requested revisions below are purely at the level of presentation and should be straightforward to implement.
Only the relatively minor revisions listed below have been requested: 1) The actual peptide sequences should be made available to the reader.
Therefore, additional experiments and clarifications (see 'essential revisions' below) are required to further strengthen the manuscript.
The mean time from primary amputation to stump revision for the below-knee amputation was significantly longer than that of the above-knee amputation (p = 0.03), probably because a lower leg prosthesis has better compensatory function and relatively lower risk to injure the stump than a thigh prosthesis.
This notion of belief satisfies the AGM axioms of belief revision presented below.
Although the paper is well written, I have a number of comments and suggestions for minor revision outlined below.
Given new findings added to the present revision (see below), we do not think Rab23's function is restricted to the D1R.
The paper should discuss the issue of damage, include some damage statistics from the present work (see item 2 in the revision requests, below), and mention the longer-term value of using a zero-loss energy filter.
However, there are some significant concerns that require major revision as outlined below.
My ideas, my truth claims, are instantaneously up for grabs, awash in the democratic sea of your criticism, your praise, your collective revision (as a look below at the comments section attests).
