Exact(1)
We have included a new supplemental figure, Figure 1 figure supplement 2, and discussed the data in the revised text (Results, first paragraph).
Similar(59)
We address this this point with revised text in Results and Discussion.
We present this comparison in the revised text, in the Results section.
sd = standard deviation; q1,q3 = quartile 1, quartile 3. The revised text in the results should read: Patients had a median of 1.0 comorbidity recorded at baseline admission, although the range was wide (0 12, not including heart failure), with some evidence of an increase in comorbidity burden over time Table two (Table 1 here).
In the revised text we now state: "These results suggest that, compared to other clinically-approved kinase inhibitors, sorafenib treatment has an increased propensity generate unexpected adverse events in a variety of physiological systems.
Due to the indirect relevance of these results to the main topic of this paper, we decided not to include these results in the revised text.
The distributions are shown in Author response image 1 below, and the results are reported in the revised text.
The results were also included in the revised text ("both ZNF644 and WIZ-binding sequences… with full-length recombinant proteins").
We refer to this issue in the revised text.
This issue is now better mentioned in revised text.
We have stated these limitations clearly in the Methods and Results sections describing the relevant experiments, as marked by comments in the revised text.
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