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The author reviewed trial documents in order to create imaginary dialogues among the thieves.
Microbiological failure, measured at varying time points, was based on blood cultures, although one reviewed trial 71 also reported bone marrow culture results for ciprofloxacin compared with chloramphenicol (67% v 100% positive cultures on day 5, P=0.04).
Whereas 1 study clinician per site reviewed trial patients, daily further clinical and nursing management was undertaken by hospital staff with access to routinely available resources only and with care supervised by the hospital pediatrician.
A number of factors may produce such beneficial outcome including more rigorous adherence to a peer reviewed trial protocol, management by an experienced treatment team, being treated in a specialist centre etc.
At the first interim analysis, the NIAID Vaccine and Prevention Data and Safety Monitoring Board reviewed trial progress in a scheduled interim analysis and concluded that, while statistical evidence neither established benefit nor harm, the available evidence ruled out targetted levels of benefit.
For instance, for the research question on effectiveness of antibiotic regimens (Question E), we found a nonindexed but peer reviewed trial on antibiotic prophylaxis by using Google Scholar, though this study had not been retrieved by a previous Cochrane systematic review [ 25].
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Nearly 14% of the reviewed trials are either not randomized or not double-blind.
Fourteen percent of the reviewed trials were either not randomized or not double-blinded.
No adverse effects were reported in any of the reviewed trials.
The outcome domains assessed in the reviewed trials were, to an extent, in-line with recognized guidelines.
We systematically reviewed trials that evaluated HIT impact on process and patient outcomes as well as costs in organ transplant care.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com