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One of the major challenges in cancer gene therapy is tumor-specific expression of therapeutic genes, and a transcriptional targeting approach will be reviewed, in reference to NPC.
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Recently, there have been considerable advances in our understanding of the mechanism of polarized growth of C. albicans hyphae (reviewed in reference 2), providing an opportunity to use C. albicans as a model to facilitate understanding of the general process of polarized growth in fungal hyphae.
Based on previous reports of sleep inertia (reviewed in reference [ 15]), we expected to see a decline in PVT performance following a nap, but were somewhat surprised by the magnitude of this decline.
To date, no consensus sequence exists for Pol IV and Pol V transcriptional targets (reviewed in reference 57) so it is difficult to identify direct targets of Pol IV-RdDM.
TGFβ is known to have pleiotropic effects which differ according to cell state and differentiation (reviewed in reference [ 1]).
Culturing methods are known to greatly underestimate microbial richness and abundance (reviewed in reference 30), and molecular techniques (e.g., next-generation sequencing) are required to more fully characterize the community.
Further, in preclinical studies GLP-1 has been shown to reduce infarct size (reviewed in reference 20).
Mammalian OST is a membrane protein consisting of seven to eight nonidentical subunits (reviewed in reference [ 110]).
In several mouse model systems of different tumor types, inactivation of Myc results in tumor regression, and in some cases, even a brief inactivation can result in long-term to permanent tumor regression (reviewed in reference [43]).
Signal peptides play a pivotal role in directing proteins to their correct cellular and extracellular compartments (reviewed in reference [ 112]).
The Mediterranean fruit fly was the first target organism to be successfully transformed using the piggyBac system [ 9] and it has subsequently been used to transform a wide variety of insects (reviewed in reference [ 10]).
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