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The US Food and Drug Administration has issued guidance that "personalized" drugs will only be reviewed in parallel with the diagnostic test that was used to select patients for the drug in its clinical trials, 65 and thus the licensed indication for vemurafenib in the US is for patients with BRAF-V600E mutant advanced melanoma as defined by the Roche cobas assay.
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Typically, one miRNA has multiple target mRNAs and, thus, can regulate several genes or even pathways in parallel (reviewed in [ 7]).
"Progress in these areas will be closely and regularly reviewed also in parallel with the financial assistance," in their words.
Phylogenies of DNA and words are not only branching but also largely parallel (reviewed in Cavalli-Sforza 1997).
Technologies reviewed in more detail are column parallel CCDs, DEPFET, vertical integration of sensors and electronics and several others which allow fast readout and low mass design.
First, the unidirectional Fano algorithm (UFA) and bidirectional Fano algorithm (BFA) are reviewed in Section 2. The novel parallel Fano decoding with scheduling architecture is proposed in Section 3. Different scheduling schemes and decoding modes are also proposed in this section.
As a consequence, software engineers review requirements in parallel with designing the software, thus partially accepting the technical risks.
The data pipeline for harvesting PubMed-SNP associations from Entrez is automated and the results are displayed in a web interface, allowing multiple users to manually review articles in parallel.
The multi-block ADM with parallel spliting is reviewed in Section 3. Unlike the classical ADM (see textbooks [32, 33]), this multi-block ADM splits the optimization variables into multiple blocks and sequentially updates just one of them while fixing the others.
Notch activity is a major player in this process (reviewed in [11], [21], [41]) and the parallel between embryonic neurogenesis and in vitro neural differentiation of ES cells is reinforced by the similar dependence on Notch signalling to maintain a population of NPs engaged on neuronal production.
Before long our independent evaluator, Rick Davies, will be doing his mid-point review in parallel with the African Medical and Research Foundation's (Amref) own evaluation, and we will be publishing these on the website in August.
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