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That is, the analytic framework provided by economic evaluation can help Cochrane reviewers to formulate an integrated systematic review of relevant economics studies, alongside the review of effectiveness studies, but which need not necessarily be restricted to the economics components of included effectiveness studies.
First, only systematic reviews were included in the review of effectiveness.
This review of effectiveness and safety focused on the randomised evidence related to the use of i.m.
First, as the aim of this review was to undertake a systematic review of economic evaluations, a systematic review of effectiveness studies was not carried out.
However, a significant finding in the review of effectiveness trials was a very high drug discontinuation rate in a short-term perspective for all the SGAs.
30 We validated the model by calibrating against key values from the Cochrane review of effectiveness of screening for abdominal aortic aneurysm.
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These efforts have highlighted both the limitations of systematic reviews of effectiveness in explaining the effects of interventions [ 5] and raised interest in synthesis in the interpretive paradigm.
As with reviews of effectiveness, a clearly focused research question is essential in a review of adverse effects.
Furthermore, the Cochrane Database and the Database of Abstracts of Reviews of Effectiveness (DARE) were reviewed.
This review has added value compared with conventional reviews of effectiveness.
Restricting systematic reviews to include only randomised studies therefore makes sense for reviews of effectiveness.
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