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We found approximately 17.2% of cases had qualitative reversion within the 1st month of treatment with an increase to 32.9% by 6 months.
The lack of reversion within HLA-restricted HCV T-cell epitopes and viral adaptation sites may suggest that mutations at these sites have limited impact on viral fitness or the cost is offset by compensatory mutations that prevent simple reversion.
Kunkel et al. [31] and Sweere et al. [32] measured the light-independent reversion of A. thaliana phyB Pfr to Pr (so-called dark reversion) and reported a relatively rapid initial dark reversion within the first 20 minutes of darkness in yeast cells.
For calculating the gfp-reversion values, we have used the value for the particular siRNA that showed maximum reversion within the set of three siRNAs.
A sub-optimal, or even failed, regimen is not an important practical concern because none of those with sputum smear reversion within two months of anti-tuberculous treatment has treatment failure.
The clinical characteristics of the two groups were similar but more patients in the Mtb group had smear reversion within the first two months of anti-tuberculous treatment and before sputum culture conversion.
Similar(47)
When compared to sequences obtained after a mean of 96 weeks of follow-up, none of HLA-A2-positive (except OP177) or HLA-A2-negative patients showed any sign of mutations or reversions within the epitope except for patient OP478 who was identified as being superinfected with a second viral variant during the first year of infection (F.M.H., unpublished data).
Recombinations usually cause multiple parallelisms or multiple reversions within a single element, whereby markers placed between these are always younger, formed after the moment of recombination.
We used predefined timepoints in controlled clinical settings that allow for the linking of genotype data with viral fitness at fixed time of the reversion process within the cohort.
In all but one case, reversion occurred within hypB (Table 1).
While within-host reversion to wild-type may well occur in the absence of selective pressure, this becomes less likely for strains with little biological impairment [35].
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